Title:
生物学的活性物質の細胞への送達のための脂質および複合体
Document Type and Number:
Japanese Patent JP6993359
Kind Code:
B2
Abstract:
A lipid comprising a tri-chain cation having a cationic head group and three or more C7-24 hydrocarbyl groups for use in non-viral gene delivery systems, for example in the formation of lipopolyplex transfection vectors. Exceptionally good nucleic acid transfection is observed when nucleic acid and targeting peptides are formulated with the lipid of the invention (or lipid formulated with a co-lipid) into a LPD complex.
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Inventors:
Helen Claire Hales
Aresa Bernice Taber
Mod Philou Mod Mustapa
Stephen Lewis Heart
Aristides Tagarakiss
Aresa Bernice Taber
Mod Philou Mod Mustapa
Stephen Lewis Heart
Aristides Tagarakiss
Application Number:
JP2018566651A
Publication Date:
January 13, 2022
Filing Date:
March 10, 2017
Export Citation:
Assignee:
Ryboquin Company Ltd
International Classes:
C07C217/08; A61K31/7088; A61K38/16; A61K47/34; A61K48/00; A61P35/00; A61P37/04; C07C219/08
Domestic Patent References:
| JP2009542582A |
Foreign References:
| WO2016027699A1 | ||||
| WO2016021683A1 |
Other References:
Organic & Biomolecular Chemistry,2008年,6(14),P.2554-2559
Tetrahedron Letters,1995年,36(13),P.2207-2210
Tetrahedron Letters,1995年,36(13),P.2207-2210
Attorney, Agent or Firm:
Kenji Sugimura
Mitsutsugu Sugimura
Kaori Oshima
Mitsutsugu Sugimura
Kaori Oshima
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