Title:
リポソームの製造方法ならびにコレステロール溶解方法
Document Type and Number:
Japanese Patent JP4857392
Kind Code:
B2
Abstract:
Methods are provided for producing liposomes, including a first mixing step of mixing one or more lipids and an aqueous solution containing a water-miscible organic solvent; a heating step of heating the mixture of the lipids and the aqueous solution to a temperature at which the lipids are dissolved in the aqueous solution; and, after the heating step, a cooling step of cooling the resulting mixture to a temperature at which liposomes are produced. By this method, liposomes with a uniform particle diameter and have a high encapsulation ratio can be easily obtained.
Inventors:
Yoshitaka Shimizu
Yasuhiko Sanbe
Yasuhiko Sanbe
Application Number:
JP2010529170A
Publication Date:
January 18, 2012
Filing Date:
December 24, 2009
Export Citation:
Assignee:
Bio Med Core Co., Ltd.
International Classes:
B01J13/04; A61K8/14; A61K8/55; A61K8/63; A61K9/127; A61Q19/00
Domestic Patent References:
| JPH03181415A | 1991-08-07 | |||
| JP2002509121A | 2002-03-26 | |||
| JP2006517594A | 2006-07-27 | |||
| JP2008255109A | 2008-10-23 | |||
| JP2004522717A | 2004-07-29 |
Foreign References:
| WO1995024201A1 | 1995-09-14 |
Attorney, Agent or Firm:
Isshiki International Patent Service Corporation