Title:
リポキシンA4類似体
Document Type and Number:
Japanese Patent JP5065315
Kind Code:
B2
Abstract:
This invention is directed to compounds useful as intermediates in the synthesis of lipoxin A4 analogs of the following formulas (I) and (II): wherein R1, R2, R3, R4 and R5 are described herein. These analogs are useful in treating inflammatory and autoimmune disorders in humans. These analogs are also useful in treating pulmonary or respiratory tract inflammation in humans.
Inventors:
Bauman, John Gee.
Guildford, William Jay.
Parkinson, John F.
Sukhbara, Berner
Sabra Maniab, Bab
Guildford, William Jay.
Parkinson, John F.
Sukhbara, Berner
Sabra Maniab, Bab
Application Number:
JP2009035743A
Publication Date:
October 31, 2012
Filing Date:
February 18, 2009
Export Citation:
Assignee:
Bayer Intellectual Property GmbH
International Classes:
C07D317/34; C07D317/40; A61K31/16; A61K31/19; A61K31/202; A61K31/216; A61K31/357; A61K31/39; A61K31/42; A61P1/02; A61P3/10; A61P7/04; A61P9/10; A61P9/12; A61P11/00; A61P13/08; A61P13/12; A61P17/00; A61P17/06; A61P19/02; A61P25/00; A61P25/06; A61P25/16; A61P25/28; A61P27/02; A61P27/16; A61P29/00; A61P31/00; A61P31/18; A61P35/00; A61P35/02; A61P37/00; A61P37/02; A61P37/06; A61P37/08; C07C59/135; C07C59/68; C07C59/70; C07C69/708; C07C69/734; C07C69/736; C07C209/68; C07C217/46; C07C229/12; C07C235/06; C07C323/52; C07D263/24; C07D317/22; C07D317/72; C07D327/04; A61P1/04; A61P7/00; A61P11/02; A61P17/04; A61P25/04
Foreign References:
| WO2000054767A1 | ||||
| WO2000055109A1 | ||||
| WO1995001179A1 | ||||
| WO2001070664A1 |
Other References:
Takano, T. et al.,Journal of Clinical Investigation,1998年 2月15日,Vol.101, No.4,p.819-826
Serhan, C. et al.,Advances in Experimental Medicine and Biology,1999年,Vol.469,p.287-293
Jane F.Maddox, et al.,Journal of Biological Chemistry,1997年,Vol.272, No.11,p.6972-6978
Serhan, C. et al.,,Biochemistry,1995年,Vol.34,p.14609-14615
GRAVIER-PELLETIER,C. et al,Lipoxins A4 and B4. Total synthesis including deprotection studies,Tetrahedron,1992年,Vol.48, No.12,pp.2441-2452
Serhan, C. et al.,Advances in Experimental Medicine and Biology,1999年,Vol.469,p.287-293
Jane F.Maddox, et al.,Journal of Biological Chemistry,1997年,Vol.272, No.11,p.6972-6978
Serhan, C. et al.,,Biochemistry,1995年,Vol.34,p.14609-14615
GRAVIER-PELLETIER,C. et al,Lipoxins A4 and B4. Total synthesis including deprotection studies,Tetrahedron,1992年,Vol.48, No.12,pp.2441-2452
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura
Yoichi Watanabe
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura
Yoichi Watanabe