PURPOSE: To provide a lipoxygenase-inhibiting compound derived from non- steroidal anti-inflammatory drug having a carboxylic acid functional group.
CONSTITUTION: A compound of formula I [R1 is H, NR2R3, OR2, SR2 (R2 and R3 are H, an alkyl, aryl or alkylaryl), optionally-substituted 1-8C alkyl, 2-8C alkenyl, arylalkyl or cycloalkyl; Y is 0 or S; n is 0 or 1; M is H, cation, or a metabolically cleavable group; Z is a residue of a non-steroidal anti- inflammatory drug of the form; Z-COOH], or a salt, ester or prodrug thereof, e.g. N-hydroxy-N-[1-(4-(2'-methylpropyl)phenyl)ethyl]urea. The compound of the formula I can be easily prepared from a compound of formula III or formula IV which is prepared by converting the carboxylic acid functional group of non-steroidal anti-inflammatory drug compound of formula II into hydroxylamine or methylenehydroxylamine.
JIYOZEFU EFU DERARIA JIYUNIA
JIEIMUZU BII SAMAAZU JIYUNIA
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