PURPOSE: To obtain the titled composition storable stably for a long period, by adding baicalin or baicalein useful as an antiallergic agent to a mixture of water and alcohol in the presence of a solubilizing stabilizer consisting of a specific amino acid and sugar or acid amide compound.
CONSTITUTION: The objective composition can be prepared by adding (A) 0.1W 0.6% baicalin of formula I or baicalein of formula II and (B) a solubilizing stabilizer consisting of (i) 0.1W1.2% amino acid (containing at least proline) and 0.1W 1.2% sugar (containing at least saccharose) or (ii) 0.1W1.2% acid amide compound (e.g. nicotinamide, thioctamide, urea, etc.) to (C) a 1:1 mixture of water and propylene glycol (or butylene glycol or ethanol). A composition which can be dissolved stably for a long period is prepared without using a surfactant, etc., by the use of the above solubilizing stabilizer. The agent is effective to allergic diseases, urticaria, itchiness, etc.
ANDO YUTAKA
MATSUI KENJI
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