Title:
2-アミノ-1,3-プロパンジオール誘導体を有効成分とする肝臓疾患治療剤および肝臓疾患治療方法
Document Type and Number:
Japanese Patent JP5116476
Kind Code:
B2
Abstract:
A novel therapeutic agent for organ disease, in particular, a therapeutic agent for liver disease is provided. It has been found that a diarylsulfide or diarylether derivative having 2-amino-1,3-propanediol structure, the compound that act as a sphingosine-1-phosphate receptor agonist, and a pharmaceutically acceptable salt and hydrate thereof are used as effective therapeutic agents for various diseases in organs, in particular liver diseases. The diarylsulfide or diarylether derivative is represented by the following general formula (1):
Inventors:
Takashi Kaneko
Eiji Kobayashi
Tokutaro Yasue
Eiji Kobayashi
Tokutaro Yasue
Application Number:
JP2007539899A
Publication Date:
January 09, 2013
Filing Date:
October 05, 2006
Export Citation:
Assignee:
Kyorin Pharmaceutical Co., Ltd.
International Classes:
A61K31/145; A61P1/16; C07C321/28
Domestic Patent References:
| JP2000154151A | 2000-06-06 |
Foreign References:
| WO2003029205A1 | 2003-04-10 | |||
| WO2003029184A1 | 2003-04-10 |
Other References:
JPN6012018063; 常松 令 他: 肝臓 Ｖｏｌ．４６， Ｎｏ．Ｓｕｐｐｌｅｍｅｎｔ ２, 200509, ｐ．Ａ４５５
JPN6012018065; ＨＥＮＥＧＨＡＮ， Ｍ．Ａ． ｅｔ ａｌ．: Ｈｅｐａｔｏｌｏｇｙ Ｖｏｌ．３５， Ｎｏ．１, 2002, ｐｐ．７-１３
JPN6012018065; ＨＥＮＥＧＨＡＮ， Ｍ．Ａ． ｅｔ ａｌ．: Ｈｅｐａｔｏｌｏｇｙ Ｖｏｌ．３５， Ｎｏ．１, 2002, ｐｐ．７-１３
Attorney, Agent or Firm:
Mizuno Katsufumi
Masayuki Kishida
Hiroshin Takano
Masayuki Kishida
Hiroshin Takano