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Title:
Biorelevant Compositions
Document Type and Number:
Japanese Patent JP6348480
Kind Code:
B2
Abstract:
Disclosed is a standardised aqueous biorelevant media for simulating fasted state stomach and fasted state upper small intestinal fluids of mammalian species, composed of surfactants occurring in the gastro intestinal tract of mammals comprising (a) at least 40 mole % to 95 mole % of one bile salt, and (b) the rest mole % being a combination of at least two surfactants, namely a diacyl phospholipid and a fatty acid including monovalent salts of the fatty acid, or a monoacyl phospholipid and a fatty acid including monovalent salts of the fatty acid, or a diacyl phospholipid and a monoacyl phospholipid and a fatty acid including monovalent salts of the fatty acid, or a diacyl phospholipid and a monoacyl phospholipid, which further is defined by a surface tension between 25 mN/m and 50 mN/m. Disclosed is further a homogeneous biorelevant composition for preparing fasted state biorelevant media characterised by a surface tension between 25 mN/m and 50 mN/m comprising the following surfactants: (a) at least 40 mole % to 95 mole % of one bile salt, and (b) the rest mole % being a combination of at least two surfactants, namely a diacyl phospholipid and a fatty acid including monovalent salts of the fatty acid, or a monoacyl phospholipid and a fatty acid including monovalent salts of the fatty acid, or a diacyl phospholipid and a monoacyl phospholipid and a fatty acid including monovalent salts of the fatty acid, or a diacyl phospholipid and a monoacyl phospholipid.

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Inventors:
Rye, Matthew Louis Steffen
Rye, Stephe
Dresman, Yenifel
Klefa, Bastian
Arunto, Marcel
Fuchs, alexander
Application Number:
JP2015502383A
Publication Date:
June 27, 2018
Filing Date:
April 02, 2013
Export Citation:
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Assignee:
Biore Levant.com Limited
International Classes:
G01N33/15; G01N33/50
Foreign References:
WO2007054342A1
WO2003042392A1
Other References:
LUNER PE et al.,J Pharm Sci.,2001年 3月,90(3),348-359
Attorney, Agent or Firm:
Masaki Yamakawa
Shigeki Yamakawa



 
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