Title:
長時間作用型アドレノメデュリン誘導体
Document Type and Number:
Japanese Patent JP6685046
Kind Code:
B2
Abstract:
There is provided a novel adrenomedullin derivative capable of sustainably acting for a longer period than natural adrenomedullin. The invention relates to a compound represented by formula (I): A-L n -B (I), wherein A is a modifying group selected from the group consisting of a palmitoyl group and a polyethylene glycol group, L is a divalent linking group, n is an integer of 0 or 1, and B is a peptide moiety derived from adrenomedullin or a modified form thereof with adrenomedullin activity, wherein the peptide moiety B is bound to the modifying group A or the linking group L via the N-terminal amino group of the peptide moiety B, or a salt thereof, or a hydrate thereof.
Inventors:
Kazuo Kitamura
Takeshi Kato
Eku Kubo
Kenji Kuwasako
Shigeru Kubo
Kumiko Kumagai
Takeshi Kato
Eku Kubo
Kenji Kuwasako
Shigeru Kubo
Kumiko Kumagai
Application Number:
JP2016508818A
Publication Date:
April 22, 2020
Filing Date:
March 20, 2015
Export Citation:
Assignee:
National University Corporation Miyazaki University
International Classes:
C07K14/47; A61K38/17; A61K47/34; A61K47/56; A61P9/00; A61P9/14; A61P29/00
Foreign References:
| WO2012138867A1 | ||||
| WO2013064508A1 | ||||
| WO2008051383A1 | ||||
| WO2002098446A1 |
Attorney, Agent or Firm:
Hiraki International Patent Office