Title:
不溶性薬剤の持効性ヘテロ分散ヒドロゲル系
Document Type and Number:
Japanese Patent JP4077886
Kind Code:
B2
Abstract:
A sustained release pharmaceutical formulation includes a sustained release excipient including a gelling agent, an inert pharmaceutical diluent, an optional cationic crosslinking agent, and a medicament having moderate to poor solubility is disclosed. In certain embodiments, the sustained release excipient is granulated with a solution or suspension of a hydrophobic polymer in an amount effective to slow the hydration of the gelling agent when the formulation is exposed to an environmental fluid. In another embodiment, the tablet is coated with a hydrophobic polymer.
Inventors:
Anand are bihibar
Application Number:
JP24076694A
Publication Date:
April 23, 2008
Filing Date:
September 09, 1994
Export Citation:
Assignee:
Penn West Pharmaceuticals Company
International Classes:
A61K47/36; A61K9/20; A61K9/22; A61K9/28; A61K9/30; A61K31/4422; A61K47/04; A61K47/10; A61K47/26; C08J3/075
Domestic Patent References:
| JP4501713A | ||||
| JP63130522A | ||||
| JP4027352A | ||||
| JP56030485A | ||||
| JP2145159A | ||||
| JP4316515A |
Foreign References:
| WO1993001803A1 |
Attorney, Agent or Firm:
Yusuke Hiraki
Ishii Teiji
Ishii Teiji