PURPOSE: To obtain the subject pharmaceutical, containing sodium chloride and/or sugaralcohol as an additive, capable of exhibiting growth hormone releasing activity in living bodies and relieving nasal mucosal irritancy of a peptide useful in clinical medicine and usable for a long period without any toxic reaction.
CONSTITUTION: A pharmaceutical containing sodium chloride and/or sugaralcohol as an additive. In use, the pharmaceutical is formed into a solution so as to enable spraying or dripping of a peptide which is an active ingredient into the nasal cavity or freeze-dried pharmaceutical from aspects of preservation stability, dissolved in a dissolving solution and employed in use. The content of the active ingredient in the pharmaceutical is normally 0.001-10wt./vol.% in an aqueous solution or suspension. Mannitol, sorbitol, etc., are cited as the sugaralcohol employed as the aforementioned additive. The amount thereof used is 0.1-30wt./vol.% in the case of the aqueous solution or suspension and the amount of the sodium chloride used is 0.01-10wt./vol.%.
TAKADA YOSHIHIRO
AISAKA AYUMI
