To provide a low permeation resin hose excellent in interlaminar adhesive properties and flexibility, and also excellent in low permeability against fuels, refrigerant or the like.

The low permeation resin hose is prepared by forming an outer layer 2 on the outer periphery of a tubular low permeation layer 1. The low permeation layer 1 is formed by using an alloy material (A) in which an island phase (domain) consisting of a modified high density polyethylene resin is dispersed in an sea phase (matrix) consisting of an ethylene-vinyl alcohol copolymer, and the outer layer 2 is formed by using a polyamide resin (B) with a high amino value.