Title:
低粘度、高濃度エボロクマブ製剤及びそれらの製造方法
Document Type and Number:
Japanese Patent JP7377596
Kind Code:
B2
Abstract:
Provided herein are formulations of PCSK9-binding polypeptides, such as those comprising evolocumab, that comprise N-acetyl arginine and have reduced viscosities when compared to formulations lacking N-acetyl arginine. Provided herein are also methods of formulating such compositions that are advantageous in that they conserve certain components. Such formulations comprising PCSK9-binding polypeptides can be administered to patients to treat and/or prevent PCSK9-related diseases, conditions, and disorders.
Inventors:
Christopher Jay Slowey
Sekar Kana plan
Ella Bina Bazi
Wang Chun Twi
Cheo Muui Chang
Sekar Kana plan
Ella Bina Bazi
Wang Chun Twi
Cheo Muui Chang
Application Number:
JP2018023742A
Publication Date:
November 10, 2023
Filing Date:
February 14, 2018
Export Citation:
Assignee:
Amjien Incorporated
International Classes:
A61K39/395; A61K9/08; A61K47/18; A61P3/06; A61P43/00
Foreign References:
| WO2016065181A1 | ||||
| WO2013166448A1 | ||||
| WO2016087569A1 | ||||
| WO2015173782A1 | ||||
| WO2007074880A1 | ||||
| WO2013012022A1 |
Attorney, Agent or Firm:
Kawaguchi International Patent Office
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