Title:
MEKインヒビターおよびその使用方法
Document Type and Number:
Japanese Patent JP5129143
Kind Code:
B2
Abstract:
Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof. Such compounds are MEK inhibitors and are useful in the treatment of proliferative diseases, such as cancer. Also disclosed are pharmaceutical compositions containing such compounds as well as methods of using the compounds and compositions of the invention in the treatment of cancer.
Inventors:
Eye, nine
Neil Kumar, Anand
Bowles, Owen Joseph
Bushenias, Jeruk
Costanzo, Simona
Curtis, Jeffrey Kimo
Dubenco, Larisa
Joshi, Anaha Abijit
Kennedy, Abigail Earl.
Kim, Angie Inyoung
Kortun, Elena
Manalo, Jean-Claire Limune
Pitot, Chaba Jay.
Rice, Kennis Dee.
Tsang, Tse H.
Diffina, Stephen Charles
Brazi, Charles M.
Neil Kumar, Anand
Bowles, Owen Joseph
Bushenias, Jeruk
Costanzo, Simona
Curtis, Jeffrey Kimo
Dubenco, Larisa
Joshi, Anaha Abijit
Kennedy, Abigail Earl.
Kim, Angie Inyoung
Kortun, Elena
Manalo, Jean-Claire Limune
Pitot, Chaba Jay.
Rice, Kennis Dee.
Tsang, Tse H.
Diffina, Stephen Charles
Brazi, Charles M.
Application Number:
JP2008534706A
Publication Date:
January 23, 2013
Filing Date:
October 05, 2006
Export Citation:
Assignee:
Exelixis, Inc.
International Classes:
C07D205/04; A61K31/397; A61K31/4025; A61K31/4155; A61K31/4178; A61K31/4184; A61K31/4192; A61K31/4196; A61K31/427; A61K31/437; A61K31/4427; A61K31/4439; A61K31/4523; A61K31/454; A61K31/4545; A61K31/496; A61K31/501; A61K31/502; A61K31/506; A61K31/53; A61K31/5377; A61K31/551; A61K31/7052; A61P17/02; A61P17/06; A61P35/00; A61P35/02; A61P43/00; C07D205/06; C07D401/04; C07D401/06; C07D401/12; C07D401/14; C07D403/04; C07D403/06; C07D403/12; C07D403/14; C07D405/12; C07D409/06; C07D413/14; C07D417/12; C07D471/04; C07H15/26
Domestic Patent References:
| JP2002532415A |
Foreign References:
| WO1999001421A1 | ||||
| WO2005051301A1 | ||||
| WO2005023759A1 | ||||
| WO2003077914A1 | ||||
| WO2003077855A1 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita