Title:
MTKIキナゾリン誘導体
Document Type and Number:
Japanese Patent JP2009542778
Kind Code:
A
Abstract:
The present invention concerns the compounds of formula the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein Y represents -C3-9alkyl-, -C1-5alkyl-NR6-C1-5alkyl- or -C1-5alkyl-NR7-CO-C1-5alkyl-; X1 represents -O -; X2 represents NR5-C1-2alkyl-; R1 represents hydrogen, halo or Het3-O-; R2 represents hydrogen; R3 represents hydroxy, C1-4alkyloxy- or C1-4alkyloxy substituted with one or two substituents each independently selected from Het4, hydroxy, C1-4alkyloxy-, C1-4alkyloxy-C1-4alkyloxy and NR9R10; R5 represents hydrogen or C1-4alkyl; R6 represents hydrogen or C1-4alkyl; R7 represents hydrogen; R9 and R10 each independently represent hydrogen; C1-4alkyl-S(=O)2-C1-4alkyl-C(=O)-; C1-4alkyl or C1-4alkyl substituted with hydroxy; Het3 represents pyridinyl optionally substituted with C1-4alkyl; Het4 represents morpholinyl, piperidinyl or piperazinyl wherein said Het4 is optionally substituted with hydroxy-C1-4alkyl or C1-4alkyl-S(=O)2-C1-4alkyl-.
Inventors:
Papanikos, Alexandra
Freinu, Eddie Jean Edgar
Ten Holt, Peter
Willems, Marc
Emblefts, Berner Constant Johann
Mehreb, Lawrence Anne
Stork, Pierre-Henri
Freinu, Eddie Jean Edgar
Ten Holt, Peter
Willems, Marc
Emblefts, Berner Constant Johann
Mehreb, Lawrence Anne
Stork, Pierre-Henri
Application Number:
JP2009518900A
Publication Date:
December 03, 2009
Filing Date:
July 12, 2007
Export Citation:
Assignee:
JANSSEN PHARMACEUTICA NAAMLOZE VENNOOTSCHAP
International Classes:
C07D498/16; A61K31/519; A61K31/5377; A61K31/541; A61P9/00; A61P9/10; A61P25/04; A61P35/00; A61P43/00
Domestic Patent References:
| JPH11504033A | 1999-04-06 | |||
| JP2004506732A | 2004-03-04 | |||
| JP2005536486A | 2005-12-02 |
Foreign References:
| WO2006061417A2 | 2006-06-15 | |||
| WO2004105765A1 | 2004-12-09 |
Attorney, Agent or Firm:
Patent business corporation Odashima patent office