Title:
ヘテロ環式Ｐ２’基を有する第ＸＩＡ因子阻害剤としてのマクロ環
Document Type and Number:
Japanese Patent JP6505727
Kind Code:
B2
Abstract:
The present invention provides compounds of Formula (I):or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and these compounds for use in therapy.
Inventors:
James Earl Court
Indawati de Lucca
Fan Tianan
Wu Yang
One Yufen
Andrew Kay Dilger
Kumar Balashanmuga Pabisetti
William Earl Ewing
Yehen Joo
Ruth Earl Wexler
Donald Jay P. Pinto
Michael Jay Owat
Leon M Smith the Second
Indawati de Lucca
Fan Tianan
Wu Yang
One Yufen
Andrew Kay Dilger
Kumar Balashanmuga Pabisetti
William Earl Ewing
Yehen Joo
Ruth Earl Wexler
Donald Jay P. Pinto
Michael Jay Owat
Leon M Smith the Second
Application Number:
JP2016549279A
Publication Date:
April 24, 2019
Filing Date:
January 30, 2015
Export Citation:
Assignee:
BRISTOL-MYERS SQUIBB COMPANY
International Classes:
C07D471/04; A61K31/506; A61P9/00; A61P9/10; A61P43/00; C07D471/06; C07D471/16; C07D487/04; C07D487/06; C07D519/00
Domestic Patent References:
| JP2013519678A |
Foreign References:
| WO2013093484A1 | ||||
| WO2013022814A1 |
Attorney, Agent or Firm:
Samejima Mutsumi
Nagatoshi Shinagawa
Kure Hidenori
Nagatoshi Shinagawa
Kure Hidenori