Title:
抗ウイルス剤としての大環状化合物
Document Type and Number:
Japanese Patent JP5433573
Kind Code:
B2
Abstract:
A class of macrocyclic compounds of formula (I), wherein R1, R3, R4, Ra, Rb, A, Z, Y, X, M, W, n and m are defined herein, that are useful as inhibitors of viral proteases, particularly the hepatitis C virus (HCV) NS3 protease, are provided. Also provided are processes 5 for the synthesis and use of such macrocyclic compounds for treating or preventing HCV infection. Formula (I):
Inventors:
Riverton, Niger
Summa, Vincenttsuo
Matsucoree, Jiyoung
Harper, Stephen
Butcher, Jiyoung
Day filippo, multi erotic
Dei franciesco, maria emilia
Fuerara, marco
Romano, Joseph Jei
Rattd, Michael
Summa, Vincenttsuo
Matsucoree, Jiyoung
Harper, Stephen
Butcher, Jiyoung
Day filippo, multi erotic
Dei franciesco, maria emilia
Fuerara, marco
Romano, Joseph Jei
Rattd, Michael
Application Number:
JP2010516598A
Publication Date:
March 05, 2014
Filing Date:
July 17, 2008
Export Citation:
Assignee:
Merck Sharp & Dohme Corp.
International Classes:
C07K5/12; A61K38/21; A61K38/55; A61P1/16; A61P31/14; A61P43/00; C07K5/06; C07K5/08
Domestic Patent References:
| JP2010507661A | ||||
| JP2009502793A | ||||
| JP2009503080A | ||||
| JP2008540415A | ||||
| JP2007534662A |
Attorney, Agent or Firm:
Yoshikazu Iwase
Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Yasufumi Shiroyama
Yoshio Kawaguchi
Chihiro Watanabe
Katsuma Osaki
Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Yasufumi Shiroyama
Yoshio Kawaguchi
Chihiro Watanabe
Katsuma Osaki