Title:
嚢胞性線維症膜コンダクタンス制御因子のモジュレーターとしての大環状分子、それらの医薬組成物、嚢胞性線維症の治療におけるそれらの使用、及びそれらの製造方法
Document Type and Number:
Japanese Patent JP7214743
Kind Code:
B2
Abstract:
Compounds of Formula (I):pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.
Inventors:
Clemens, Jeremy Jay.
Avella, Alexander Russell
Anderson, Corey Don
Bush, Brett Bee.
Chen, Weichao George
Cleveland, Thomas
Kuhn, Timothy Richard
freeman, brian
Gilmay, Senite G.
Gruten Yuis, Peter
Gurbik, Anton Buoy.
Hadi Darua, Sara Sabina
Shea, Clara Kuang-ju
can pin
Katsuya, Haripada
McCartney, Jason
Mirror, Mark Thomas
Paraselli, Plasna
Pierre, Fabrice
Swift, Sarah Yee.
Theremin, Andreas
Ui, Johnny
Vogel, Carl Buoy.
Jou, Jinlan
Avella, Alexander Russell
Anderson, Corey Don
Bush, Brett Bee.
Chen, Weichao George
Cleveland, Thomas
Kuhn, Timothy Richard
freeman, brian
Gilmay, Senite G.
Gruten Yuis, Peter
Gurbik, Anton Buoy.
Hadi Darua, Sara Sabina
Shea, Clara Kuang-ju
can pin
Katsuya, Haripada
McCartney, Jason
Mirror, Mark Thomas
Paraselli, Plasna
Pierre, Fabrice
Swift, Sarah Yee.
Theremin, Andreas
Ui, Johnny
Vogel, Carl Buoy.
Jou, Jinlan
Application Number:
JP2020543326A
Publication Date:
January 30, 2023
Filing Date:
February 14, 2019
Export Citation:
Assignee:
VERTEX PHARMACEUTICALS INCORPORATED
International Classes:
C07D513/18; A61K31/404; A61K31/437; A61K31/439; A61K31/47; A61P1/04; A61P1/18; A61P11/00; A61P15/00; A61P43/00; C07D513/22; C07D515/18; C07D515/22; C07D519/00
Domestic Patent References:
| JP2017530167A | ||||
| JP2019529490A | ||||
| JP6916285B2 | ||||
| JP2021512117A | ||||
| JP2014526500A |
Foreign References:
| WO2017173274A1 |
Other References:
BASTIN,R.J. et al.,Salt selection and optimization procedures for pharmaceutical new chemical entities,Organic Process Research & Development,2000年,Vol.4, No.5,p.427-435
Attorney, Agent or Firm:
Shusaku Yamamoto
Morishita Natsuki
Morishita Natsuki