Title:
MACROCYCLIC MOLECULES AS MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR, PHARMACEUTICAL COMPOSITIONS THEREOF, USE THEREOF IN TREATMENT OF CYSTIC FIBROSIS, AND PRODUCTION METHODS THEREFOR
Document Type and Number:
Japanese Patent JP2022126802
Kind Code:
A
Abstract:
To provide macrocyclic molecules as modulators of the cystic fibrosis transmembrane conductance regulator.SOLUTION: Disclosed herein are compounds of Formula (I) in the figure, and pharmaceutically acceptable salts, deuterated derivatives, and metabolites thereof. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for producing the same are also disclosed.SELECTED DRAWING: Figure 1-1
Inventors:
JEREMY J CLEMENS
ALEXANDER RUSSELL ABELA
COREY DON ANDERSON
BUSCH BRETT B
CHEN WEICHAO G
THOMAS CLEVELAND
TIMOTHY RICHARD COON
FREEMAN BRIAN
SENAIT G GHIRMAI
PETER GROOTENHUIS
ANTON V GULEVICH
SARA SABINA HADIDA RUAH
CLARA KUANG-JU HSIA
KANG PING
HARIPADA KATSUYA
MCCARTNEY JASON
MARK THOMAS MILLER
PRASUNA PARASELLI
FABRICE PIERRE
SARA E SWIFT
ANDREAS TERMIN
ZHOU JINGLAN
JOHNNY UY
CARL V VOGEL
ALEXANDER RUSSELL ABELA
COREY DON ANDERSON
BUSCH BRETT B
CHEN WEICHAO G
THOMAS CLEVELAND
TIMOTHY RICHARD COON
FREEMAN BRIAN
SENAIT G GHIRMAI
PETER GROOTENHUIS
ANTON V GULEVICH
SARA SABINA HADIDA RUAH
CLARA KUANG-JU HSIA
KANG PING
HARIPADA KATSUYA
MCCARTNEY JASON
MARK THOMAS MILLER
PRASUNA PARASELLI
FABRICE PIERRE
SARA E SWIFT
ANDREAS TERMIN
ZHOU JINGLAN
JOHNNY UY
CARL V VOGEL
Application Number:
JP2022100979A
Publication Date:
August 30, 2022
Filing Date:
June 23, 2022
Export Citation:
Assignee:
VERTEX PHARMA
International Classes:
C07D513/18; A61K31/404; A61K31/439; A61K31/47; A61P43/00; C07D401/14; C07D405/14; C07D513/22; C07D515/22; C07D519/00
Attorney, Agent or Firm:
Shusaku Yamamoto
Morishita Natsuki
Morishita Natsuki