Title:
MACROLIDE
Document Type and Number:
Japanese Patent JP2011126894
Kind Code:
A
Abstract:
To provide azithromycin having a stable monohydrate form and a method for preparing azithromycin in the form of e.g. a stable monohydrate.
The preparation method comprises (i) a step of treating azithromycin with hydrogen boride, (ii) a step of hydrolyzing the formed intermediate boric acid ester compound in the presence of a polyhydroxylated compound and, if desired, (iii) a step of separating the azithromycin compound from the reaction mixture.
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Inventors:
CENTELLAS VICTOR
GARCIA RAFAEL
POCH MARTA
DIAGO JOSE
LUDESCHER JOHANNES
BOSCH IMMACULADA
GARCIA RAFAEL
POCH MARTA
DIAGO JOSE
LUDESCHER JOHANNES
BOSCH IMMACULADA
Application Number:
JP2011017553A
Publication Date:
June 30, 2011
Filing Date:
January 31, 2011
Export Citation:
Assignee:
SANDOZ AG
International Classes:
C07H17/00; A61K31/7048; A61K31/7052; A61P31/04; C07H17/08
Domestic Patent References:
JPH1072482A | 1998-03-17 | |||
JPS5931794A | 1984-02-20 | |||
JPS6438096A | 1989-02-08 |
Foreign References:
WO1999002541A2 | 1999-01-21 |
Attorney, Agent or Firm:
Yoshio Kawaguchi
Katsuma Osaki
Katsuma Osaki