Title:
MAGE-A1 PEPTIDE PRESENTED BY HLA CLASS II MOLECULE
Document Type and Number:
Japanese Patent JP2008109928
Kind Code:
A
Abstract:
To provide an isolated MAGE-A1 peptide binding HLA class II molecule, and a functional variant of such the peptide.
Provided are the HLA class II peptide encoded by MAGE-A1 tumor-related gene, the nucleic acid encoding such the peptide, and the antibody associated therewith. The peptide stimulates the activity and proliferation of CD4+ T-lymphocyte. The peptide is used for the method and product for diagnosing and treating symptom characterized by the expression of the MAGE-A1 gene.
Inventors:
VAN SNICK JACQUES
LETHE BERNARD
CHAUX PASCAL
BOON-FALLEUR THIERRY
VAN DER BRUGGEN PIERRE
LETHE BERNARD
CHAUX PASCAL
BOON-FALLEUR THIERRY
VAN DER BRUGGEN PIERRE
Application Number:
JP2007270239A
Publication Date:
May 15, 2008
Filing Date:
October 17, 2007
Export Citation:
Assignee:
LUDWIG INST CANCER RES
International Classes:
C12N15/09; A61K38/00; A61K45/00; A61P35/00; A61P35/02; C07K7/08; C07K14/47; C07K14/82; C07K16/32; C12N1/15; C12N1/19; C12N1/21; C12N5/07; C12N5/0783; C12N5/10; C12P21/08; C12Q1/02; G01N33/53
Domestic Patent References:
| JP2003502079A | 2003-01-21 |
Foreign References:
| WO1996026214A1 | 1996-08-29 |
Attorney, Agent or Firm:
Kiyoji Kuzuwa
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