Title:
マグネシウム含有オキシトシン製剤および使用の方法
Document Type and Number:
Japanese Patent JP7455402
Kind Code:
B2
Abstract:
Disclosed are magnesium-containing oxytocin peptide formulations or compositions comprising an oxytocin peptide and a magnesium salt that produces synergistic analgesia when used in treating pain. Also disclosed are methods for the treatment of pain (such as migraine headache) comprising co-administration of an oxytocin peptide and a magnesium salt.
Inventors:
David Sea. Yomans
Dean Carson
Ramachandran Silcourt
Dean Carson
Ramachandran Silcourt
Application Number:
JP2021179295A
Publication Date:
March 26, 2024
Filing Date:
November 02, 2021
Export Citation:
Assignee:
Trigemina, Incorporated
International Classes:
A61K38/095; A61K9/08; A61K33/06; A61M11/00; A61M15/08; A61P25/04; A61P25/06; A61P43/00
Domestic Patent References:
| JP2009506071A | ||||
| JP2002518456A |
Other References:
Wang, Y. L. et al.,The interaction between the oxytocin and pain modulation in headache patients,Neuropeptides,2013年,Vol.47, No.2,p.93-97,doi:10.1016/j.npep.2012.12.003
Mauskop, A. et al.,Intravenous magnesium sulfate rapidly alleviates headaches of various types,Headache,1996年,Vol.36, No.3,p.154-160,doi:10.1046/j.1526-4610.1996.3603154.x
金 浩澤, 島津 邦男,片頭痛の病態生理とその進展,綜合臨床,2000年06月,第49巻,第6号,p.1767-1770
Avanti, C. et al.,A new strategy to stabilize oxytocin in aqueous solutions: II. Suppression of cysteine-mediated intermolecular reactions by a combination of divalent metal ions and citrate,Molecular Pharmaceutics,2012年,Vol.9, No.3,p.554-562,doi:10.1021/mp200622z
Mauskop, A. et al.,Intravenous magnesium sulfate rapidly alleviates headaches of various types,Headache,1996年,Vol.36, No.3,p.154-160,doi:10.1046/j.1526-4610.1996.3603154.x
金 浩澤, 島津 邦男,片頭痛の病態生理とその進展,綜合臨床,2000年06月,第49巻,第6号,p.1767-1770
Avanti, C. et al.,A new strategy to stabilize oxytocin in aqueous solutions: II. Suppression of cysteine-mediated intermolecular reactions by a combination of divalent metal ions and citrate,Molecular Pharmaceutics,2012年,Vol.9, No.3,p.554-562,doi:10.1021/mp200622z
Attorney, Agent or Firm:
Shusaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto