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Title:
MALONAMIDE DERIVATIVE BLOCKING ACTIVITY OF GAMMA-SECRETASE
Document Type and Number:
Japanese Patent JP2010229153
Kind Code:
A
Abstract:

To provide compounds blocking activity of γ-secretase able to be used for treating Alzheimer's disease.

Malonamide derivatives expressed by formula (I) [in formula (I), R1 represents a group expressed by formula (a)], pharmaceutically suitable acid addition salts, optically pure enantiomers, racemates or diastereomeric mixtures thereof are provided.


Inventors:
FLOHR ALEXANDER
GALLEY GUIDO
JAKOB-ROETNE ROLAND
KITAS ERIC ARGIRIOS
PETERS JENS-UWE
WOSTL WOLFGANG
Application Number:
JP2010138970A
Publication Date:
October 14, 2010
Filing Date:
June 18, 2010
Export Citation:
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Assignee:
HOFFMANN LA ROCHE
International Classes:
C07D223/18; A61K31/335; A61K31/55; A61K31/5513; A61P25/28; A61P43/00; C07D223/16; C07D223/20; C07D243/24; C07D273/00; C07D313/14
Domestic Patent References:
JP2003534333A2003-11-18
JP2004500419A2004-01-08
JP2006516556A2006-07-06
JP4571639B22010-10-27
Attorney, Agent or Firm:
Hajime Tsukuni
Fusayuki Saito
Yoko Tanaka



 
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