Title:
MANUFACTURE OF 2-AMINO-3-CYANO-5-DIALKOXYMETHYL-PYRAZINE ANDINTERMEDIATE THEREFOR
Document Type and Number:
Japanese Patent JPS6172766
Kind Code:
A
Abstract:
2-Amino-3-cyano-5-dialkoxymethylpyrazine derivatives of the general formula III (III) where R1 and R2 are each hydrogen or a protective group usually employed for amino groups and R5 and R6 are each alkyl of 1 to 4 carbon atoms, or together form an ethylene or propylene radical which is unsubstituted or substituted by methyl, are prepared starting from a novel 3-halomethyl-5-dihalomethyl-2-aminopyrazine derivative of the formula IV (IV) where X is Cl or Br, via a novel intermediate of the general formula I (I) where R3 is -CH2-O-CO-CH3 (a), -CH2OH (b), (c) or -C 3BOND N (d) and R4 is -CHCl2 or -CHBr2 or, where R1 and R2 are each a protective group, R4 may furthermore be The compounds according to the invention are useful intermediates for the preparation of folic acid and active compounds derived from this.
Inventors:
HARUTOMUUTO RANINGAA
UORUFUGANGU RITSUTOMAN
YOAHIMU PASUTO
UORUFUGANGU RITSUTOMAN
YOAHIMU PASUTO
Application Number:
JP19963585A
Publication Date:
April 14, 1986
Filing Date:
September 11, 1985
Export Citation:
Assignee:
BASF AG
International Classes:
C07D241/20; C07D241/26; C07D403/04; C07D475/04; (IPC1-7): C07D209/00; C07D241/00; C07D241/20; C07D241/26; C07D403/04; C07D475/04
Attorney, Agent or Firm:
Toshio Yano (2 outside)