Title:
MANUFACTURE OF ALPHA-L-PHENYLALANINE ALKYL ESTER
Document Type and Number:
Japanese Patent JPS5782356
Kind Code:
A
Abstract:
1. A method for preparing an Alpha-L-aspartyl-L-phenylalanine alkyl ester, characterised in a) reacting a divalent alkali salt of L-aspartic acid, having an amino-protective group, with an organic halo ester compound, to form a monovalent, alkali-salt, mixed, anhydride aspartate compound ; and b) condensing the mixed, anhydride, aspartate compound with an alkyl ester of L-phenylalanine under alkaline conditions and reducing the pH to an acidic condition after condensation to free the amino and carboxyl groups, to form a mixture consisting essentially of the alpha and beta alkyl ester of L-aspartyl-L-phenylalanine ; and c) separating the alpha isomer from the alpha and beta mixture.
Inventors:
PURACHIFUADEIPUHAIANKARAMU ESU
BASANTO KEE DOBUIBUEDEI
BASANTO KEE DOBUIBUEDEI
Application Number:
JP14647081A
Publication Date:
May 22, 1982
Filing Date:
September 18, 1981
Export Citation:
Assignee:
CHIMICASA GMBH
International Classes:
A23L27/30; C07C231/02; C07K5/075; (IPC1-7): C07C102/04; C07C103/52