Manufacture of an amino acid connection machine by which conjugate was carried out to a compound used for target type imaging of a tumor, and a composite method

Title:

Manufacture of an amino acid connection machine by which conjugate was carried out to a compound used for target type imaging of a tumor, and a composite method

Document Type and Number:

Japanese Patent JP2016512814

Kind Code:

A

Abstract:

近赤外線蛍光プローブとして有用な化合物であって、ｉ）標的受容体タンパク質に結合するプテロイルリガンド、ｉｉ）色素分子およびｉｉｉ）アミノ酸またはその誘導体を含むリンカー分子を含む化合物のための、合成方法および有用な組成物。本開示は、診断法の分野にある。本開示は、腫瘍の標的画像化に使用される化合物にコンジュゲートしているアミノ酸連結基を合成および利用する方法を提供する。アミノ酸連結基のコンジュゲーションは、化合物の特異性および検出を増大させる。診断用画像化におけるその使用のための化合物の製造方法および合成が想定される。

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Inventors:

Claratone, Smith A.
Gagare, Prabin
Peach, Mohammad

Application Number:

JP2016500094A

Publication Date:

May 09, 2016

Filing Date:

October 04, 2013

Export Citation:

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Assignee:

On Target Laboratories LLC

International Classes:

C07D475/04

Foreign References:

WO2010102238A1	2010-09-10
WO2007139815A2	2007-12-06
US4337339A	1982-06-29

Attorney, Agent or Firm:

Hidesaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto

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