Title:
MANUFACTURE OF CYCLOPROPANE CARBOXYLIC ACID ESTER DERIVATIVE
Document Type and Number:
Japanese Patent JPS56166163
Kind Code:
A
Abstract:
This invention relates to the preparation of cyclopropane carboxylic acid ester derivatives, which are useful as pesticides. There is provided a process for preparing a 1:1 mixture of 1R cis S- and 1S cis R- isomers substantially free of 1S cis S- and 1R cis R- isomers of a compound of formula: (I) wherein R1 and R2 are each independently selected from chlorine, bromine and methyl, which process comprises dissolving a mixture of 1S cis S- and 1R cis R- isomers of the compound of formula I, alone or in the presence of 1R cis S- and 1S cis R-isomers, in organic amine base containing from 5 to 7 carbon atoms and being a secondary amine containing two branched alkyl groups or a tertiary amine, and crystallizing out from the resulting solution of cis - isomers of formula I in the organic amine base a 1:1 mixture of the 1R cis S- and 1S cis R- isomers substantially free of 1S cis S- and 1R cis R- isomers. The process of the invention yields a product which contains substantially twice as much of the most active isomer of the compound of formula I as a racemic mixture of all four cis - isomers, and is a readily effected process which does not involve any asymmetric synthesis or optical resolution steps.
Inventors:
RONARUDO FURANKU MEISUN
DEREKU AREKISANDAA UTSUDO
DEREKU AREKISANDAA UTSUDO
Application Number:
JP5929281A
Publication Date:
December 21, 1981
Filing Date:
April 21, 1981
Export Citation:
Assignee:
SHELL INT RESEARCH
International Classes:
A01N53/14; C07B57/00; C07C67/00; C07C255/39; C07C69/74; C07C253/00; C07C253/34; C07C255/53; (IPC1-7): A01N53/00; C07C120/00; C07C121/75
Domestic Patent References:
| JPS52131559A | 1977-11-04 | |||
| JPS52148040A | 1977-12-08 |
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