Title:
MANUFACTURE OF INTERMEDIATE FOR BIOLOGICALLY ACTIVE COMPOUND
Document Type and Number:
Japanese Patent JPS638346
Kind Code:
A
Abstract:
An enantioselective process for the preparation of homoallyl alcohol enantiomer of formula II wherein: X<1>, X<2> and X<3> are independently chosen from the group consisting of hydrogen, chlorine, bromine, fluorine, iodine, C1 to C6 alkyl, C1 to C6 haloalkyl, and haloaryl; and R<1>, R<2>, R<3> and R<4> are independently chosen from the group consisting of hydrogen, halogen, alkyl, alkenyl, alkynyl, benzyl, substituted benzyl, phenyl, substituted phenyl; or R<3> and R<4> is as hereinbefore defined and R<1> and R<2> form a carbocyclic or heterocyclic ring; which process comprises; reacting an aldehyde of formula III with an alkene of formula IV in the presence of an optically-active organometallic catalyst. Furthermore, the compound of formula II can be isomerised to the allylic alcohol of formula I with retention of optical purity. n
Inventors:
GREDLEY MATTHEW (AU)
WILSHIRE COLIN (AU)
WILSHIRE COLIN (AU)
Application Number:
JP8310287A
Publication Date:
January 14, 1988
Filing Date:
April 06, 1987
Export Citation:
Assignee:
ICI AUSTRALIA LTD
International Classes:
C07B31/00; C07B53/00; C07C27/00; C07C29/14; C07C29/38; C07C33/42; C07B41/02; C07C33/48; C07C39/44; C07C67/00; C07F7/00; C07F7/28; (IPC1-7): C07B41/02; C07C29/38; C07C33/42; C07C33/48; C07F7/28
Attorney, Agent or Firm:
Aoki Akira
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