Title:
MANUFACTURE OF NUCLEOSIDE DERIVATIVE
Document Type and Number:
Japanese Patent JPS61197591
Kind Code:
A
Abstract:
A novel process for the preparation of a conjugate of a 21-hydroxy steroid and a nucleoside-5'-monophosphate comprises reacting the 21-hydroxy steroid with a derivative of the nucleoside-5'-monophosphate (in which hydroxy groups on the carbohydrate ring are protected) in the presence of 2,4,6-triisopropylbenzene sulphonyl chloride (TPS) as a condensing agent under anhydrous conditions and removing the hydroxy protecting groups from the conjugate thereby obtained. Such conjugates and their salts are useful as anticancer and antiviral agents.
Inventors:
CHIYAN IRU HON
Application Number:
JP27585285A
Publication Date:
September 01, 1986
Filing Date:
December 07, 1985
Export Citation:
Assignee:
HONEI SEIYAKU KK
International Classes:
C07H19/16; A61K31/70; A61K31/704; A61K31/7042; A61K31/7052; A61K31/706; A61K31/7064; A61K31/7072; A61K31/7076; A61P31/12; A61P35/00; C07H19/10; C07H19/12; C07H19/14; C07H19/20; C07H19/207; C07J43/00; C07J51/00; (IPC1-7): A61K31/705; C07J51/00
Attorney, Agent or Firm:
Kyozo Yuasa