Title:
MANUFACTURE OF ORGANIC COMPOUND
Document Type and Number:
Japanese Patent JPS5697236
Kind Code:
A
Abstract:
Biphenyl compounds are prepared by coupling an aniline and a benzene in the presence of a C1-6 alkyl nitrite, preferably in the additional presence of copper. The process can be used to prepare 2-fluoro- 4-halobiphenyls which are useful in the preparation of the anti-inflammatory agent flurbiprofen.
Inventors:
TOOMASU ANSONII HIRUTON
Application Number:
JP17915280A
Publication Date:
August 05, 1981
Filing Date:
December 19, 1980
Export Citation:
Assignee:
UPJOHN CO
International Classes:
C07B31/00; C07B37/04; C07C17/00; C07C17/26; C07C17/263; C07C69/65; C07C25/18; C07C51/00; C07C51/15; C07C57/58; C07C67/00; C07C209/00; C07C211/52; (IPC1-7): C07B27/00; C07C25/18; C07C57/58; C07C69/65; C07C87/60