Title:
MANUFACTURE OF PROSTAGLANDIN HOMOLOGUE
Document Type and Number:
Japanese Patent JPS59210065
Kind Code:
A
Abstract:
An improved method for the preparation of prostaglandin analogs which comprises preparation of two equivalents of an alkyl or alkenyl lithium reagent in an aprotic solvent mixture such as pentane or hexane and tetrahydrofuran, conversion of said reagent by addition of 1 equivalent of copper (I) cyanide to a copper reagent, conversion of said copper reagent to the blocked prostaglandin analog by the addition of a 2-alkylcyclopent-2-en-1-one reagent and quenching of the resultant reaction mixture with aprotic media or an active acylating agent and finally optionally deblocking the resultant product is disclosed. This method is an improvement over previous methods in that more modest temperatures and less hazardous and/or less complex reagents are used and in that for some analogs the method is shorter than previous methods.
Inventors:
POORU EFU KOREI
HARORUDO SHII KURUENDAA
HARORUDO SHII KURUENDAA
Application Number:
JP5852384A
Publication Date:
November 28, 1984
Filing Date:
March 28, 1984
Export Citation:
Assignee:
MILES LAB
International Classes:
C07C67/00; C07C401/00; C07C405/00; C07F7/18; C07F7/22; A61K31/557; (IPC1-7): C07C177/00; C07F7/18
Attorney, Agent or Firm:
Heiyoshi Odashima
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