Title:
MANUFACTURE OF STEROIDIC 33OXOO4*66DIENE
Document Type and Number:
Japanese Patent JPS5495554
Kind Code:
A
Abstract:
A process for preparing 17-hydroxy-3-oxo-17 alpha -pregna-4,6-diene-21-carboxylic acid gamma -lactone by contacting 17-hydroxy-3-oxy-17 alpha -pregna-3,5-diene-21-carboxylic acid gamma -lactone with an appropriate halogenating agent in the presence of an amine base, the corresponding hydrohalide salt thereof, and approximately 1-2 molar equivalents (relative to the lactonic starting material) of water, using a cold solvent as the contact medium, and heating the resultant mixture with a dehydrohalogenating agent, is disclosed.
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Inventors:
HIYUU RATEIMAA DORAIDEN
GEIRU MIRUTON UEBAA
GEIRU MIRUTON UEBAA
Application Number:
JP14894678A
Publication Date:
July 28, 1979
Filing Date:
December 01, 1978
Export Citation:
Assignee:
SEARLE & CO
International Classes:
C07J21/00; C07J1/00; (IPC1-7): C07J21/00