Title:
MANUFACTURING METHOD OF BENZOIC ACID COMPOUND
Document Type and Number:
Japanese Patent JP2020002108
Kind Code:
A
Abstract:
To provide a simple and high yield manufacturing method of 3-[(aminoiminomethyl)amino]-4-methylbenzoic acid (C1 to C4 alkyl)ester sulfate and ester thereof.SOLUTION: There is provided a method for manufacturing 3-[(aminoiminomethyl)amino]-4-methylbenzoic acid (C1 to C4 alkyl)ester sulfate (sulfate of the formula 2) from 3-amino-4-methylbenzoic acid (C1 to C4 alkyl)ester and cyanamide. In the formula Rrepresents a C1 to C4 alkyl group. Further there is provided a simple and high yield 4-methyl-3-{[4-(pyridine-3-yl)pyrimidine-2-yl]amino}-benzoic acid which is a manufacturing intermediate of nilotinib using the compound.SELECTED DRAWING: None
Inventors:
KUMAZAWA YOJI
NISHIMORI NOBUAKI
OKURA YUKA
NISHIMORI NOBUAKI
OKURA YUKA
Application Number:
JP2018125301A
Publication Date:
January 09, 2020
Filing Date:
June 29, 2018
Export Citation:
Assignee:
SUMITOMO CHEMICAL CO
International Classes:
C07C279/18; C07C277/08; C07D401/04
Domestic Patent References:
| JP2005533827A | 2005-11-10 | |||
| JPS504038A | 1975-01-16 |
Foreign References:
| CN103694145A | 2014-04-02 |
Other References:
JOURNAL OF CHEMICAL RESEARCH, vol. Vol.39(4), JPN6022005544, 2015, pages 223 - 225, ISSN: 0004705703
Attorney, Agent or Firm:
Patent Business Corporation Saegusa International Patent Office