Title:
微細な医薬品材料の製造方法
Document Type and Number:
Japanese Patent JP4870300
Kind Code:
B2
Abstract:
A method of producing fine medicament particles suitable for inhalation, particles produced by the method and apparatus suitable for carrying out the method. The method comprises contacting a stream or streams of a solution of medicament with a stream or streams of a liquid in which the medicament is insoluble in a confined chamber such that a region of intense turbulence and mixing is formed. The medicament crystallises as fine particles with minimal inclusion of solvent or anti-solvent impurities. The crystallised medicament is separated from suspension by standard techniques. Careful control of relative stream velocity, solution concentration and proportion of solution and anti-solvent in the streams ensures a uniform product.
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Inventors:
Dominic Begorn
Pfefe Guillaume
Michael Cole
Pfefe Guillaume
Michael Cole
Application Number:
JP2001518166A
Publication Date:
February 08, 2012
Filing Date:
August 18, 2000
Export Citation:
Assignee:
Aventis Fuma Limited
International Classes:
A61K9/14; A61K9/00; A61K9/12; A61K9/16; A61K31/57; A61L9/04; A61P11/06; B01D9/00; B01D9/02; B01F5/02; B01F3/08; B01F5/00; B01F13/00
Domestic Patent References:
| JPH04231960A | 1992-08-20 |
Foreign References:
| US0741756A | 1903-10-20 |
Attorney, Agent or Firm:
Junji Yuda
Chika Takagi
Kosuke Nishimura
Chika Takagi
Kosuke Nishimura