Title:
注射可能な医薬調製剤の製法
Document Type and Number:
Japanese Patent JP5871483
Kind Code:
B2
Abstract:
Production of an injectable pharmaceutical composition comprises dissolving a drug derivative (I) in an injectable carrier liquid, where (I) comprises a drug linked to a protein-binding group via a spacer and where the spacer or the linkage between the drug and the spacer is pH-dependently or enzymatically cleavable in vivo to release the drug. An independent claim is also included for a drug derivative of type (I) in which the drug is not a cytostatic agent.
Inventors:
Felix Kratz
Application Number:
JP2011102053A
Publication Date:
March 01, 2016
Filing Date:
April 28, 2011
Export Citation:
Assignee:
KTB Tumorforschungs GmbH
International Classes:
A61K47/48; A61K31/136; A61K31/704; A61K49/00; A61P35/00; A61P43/00
Domestic Patent References:
| JP9503511A | ||||
| JP10505835A | ||||
| JP2001500133A | ||||
| JP2002514188A |
Foreign References:
| DE19636889A | ||||
| WO1998017325A2 |
Other References:
Felix KRATZら、“Preparation,Characterization and in Vitro Efficacy of Albumin Conjugates of Doxorubicin”、Biological and Pharmaceutical Bulletin、1998年、21巻1号、56~61頁
YASUHIRO HOSAKAら、“HEMOLYSIS AND FUSION BY INFLUENZA VIRUSES WITH HEAT-INACTIVATED NEURAMINIDASE ACTIVITY”、BIKEN JOURNAL、1982年、25巻、51~62頁
Gene M.Dubowchikら、“CATHEPSIN B-SENSITIVE DIPEPTIDE PRODRUGS.1.A MODEL STUDY OF STRUCTURAL REQUIREMENTS FOR EFFICIENT RELEASE OF DOXORUBICIN”、Bioorganic & Medicinal Chemistry Letters、1998年、8巻23号、3341~3346頁
Sarah Netzel-Arnettら、“Comparative Sequence Specificities of Human 72- and 92-kDa Gelatinases(Type IV Collagenases) and PUMP(Matrilysin)”、Biochemistry、1993年、32巻25号、6427~6432頁
David Willnerら、“(6-Maleimidocaproyl)hydrazone of Doxorubicin-A New Derivative for the Preparation of Immunoconjugates of Doxorubicin”、1993年、4巻6号、521~527頁
G.R.Gapskiら、“Synthesis of a Fluorescent Derivative of Amethopterin”、Journal of Medicinal Chemistry、1975年、18巻5号、526~528頁
U.Beyerら、“Synthese von neuen bifunktionellen Maleinimidverbindungen zur Herstellung von Chemoimmunokonjugaten”、Monatshefte fur Chemie、1997年、128巻、91~102頁
Marieta Nichiforら、“Macromolecular prodrugs of 5-fluorouracil.2:Enzymatic degradation”、Journal of Controlled Release、1996年、39巻、79~92頁
YASUHIRO HOSAKAら、“HEMOLYSIS AND FUSION BY INFLUENZA VIRUSES WITH HEAT-INACTIVATED NEURAMINIDASE ACTIVITY”、BIKEN JOURNAL、1982年、25巻、51~62頁
Gene M.Dubowchikら、“CATHEPSIN B-SENSITIVE DIPEPTIDE PRODRUGS.1.A MODEL STUDY OF STRUCTURAL REQUIREMENTS FOR EFFICIENT RELEASE OF DOXORUBICIN”、Bioorganic & Medicinal Chemistry Letters、1998年、8巻23号、3341~3346頁
Sarah Netzel-Arnettら、“Comparative Sequence Specificities of Human 72- and 92-kDa Gelatinases(Type IV Collagenases) and PUMP(Matrilysin)”、Biochemistry、1993年、32巻25号、6427~6432頁
David Willnerら、“(6-Maleimidocaproyl)hydrazone of Doxorubicin-A New Derivative for the Preparation of Immunoconjugates of Doxorubicin”、1993年、4巻6号、521~527頁
G.R.Gapskiら、“Synthesis of a Fluorescent Derivative of Amethopterin”、Journal of Medicinal Chemistry、1975年、18巻5号、526~528頁
U.Beyerら、“Synthese von neuen bifunktionellen Maleinimidverbindungen zur Herstellung von Chemoimmunokonjugaten”、Monatshefte fur Chemie、1997年、128巻、91~102頁
Marieta Nichiforら、“Macromolecular prodrugs of 5-fluorouracil.2:Enzymatic degradation”、Journal of Controlled Release、1996年、39巻、79~92頁
Attorney, Agent or Firm:
Einzel Felix-Reinhard
Takuya Kuno
Shuichi Sumiyoshi
Takuya Kuno
Shuichi Sumiyoshi
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