Title:
MANUFACTURING METHOD OF OPTICAL ACTIVE SECONDARY ALCOHOL
Document Type and Number:
Japanese Patent JP2019011367
Kind Code:
A
Abstract:
To provide a method for manufacturing optical active secondary alcohol with high optical purity by hydrogenating a substrate carbonyl compound using a ruthenium complex with a specific optical active diphosphine compound and an amine compound of which synthesis is easy as ligands as a catalyst.SOLUTION: The manufacturing method of optical active secondary alcohol including reacting a substrate carbonyl compound (excluding 3-quinuclidinone, a 3-quinuclidinone derivative having a substituent, and ketone having an aromatic hydrocarbon group and a heterocycle) with hydrogen and/or a hydrogen-donating compound in a presence of a ruthenium complex selected from a compound represented by the following general formula (1) RuXYAB (1) [X and Y are same or different, represent a hydrogen atom or an anionic group, A represents optical active diphosphine represented by the general formula (2), and B represents an amine compound represented by the following general formula (3)].SELECTED DRAWING: None
Inventors:
KATAYAMA TAKEAKI
TSUTSUMI KUNIHIKO
MURATA KUNIHIKO
OKUMA TAKESHI
ARAI NORIYOSHI
TSUTSUMI KUNIHIKO
MURATA KUNIHIKO
OKUMA TAKESHI
ARAI NORIYOSHI
Application Number:
JP2018193264A
Publication Date:
January 24, 2019
Filing Date:
October 12, 2018
Export Citation:
Assignee:
KANTO KAGAKU
UNIV HOKKAIDO
UNIV HOKKAIDO
International Classes:
C07C29/145; B01J31/24; C07C33/20; C07C33/46; C07C43/205
Attorney, Agent or Firm:
Kiyoji Kuzuwa