Title:
間葉系幹細胞亜集団および破骨細胞に対するマーカー、抗体および組換えscFv
Document Type and Number:
Japanese Patent JP2010520761
Kind Code:
A
Abstract:
Abstract Markers, antibodies and recombinant scFvs for Mesenchymal Stem Cell sub-populations and osteoclasts. The present invention relates to specific epitopes of surface membrane bound glycoproteins expressed by mesenchymal stem cells and pre-osteoclasts and relates to antibodies such as monoclonal antibodies and recombinant scFv or fragments thereof, raised to the particular epitope and their use in identifying, isolating, and characterization of mesenchymal stem cell sub-populations such as that termed “Stromal Progenitor Cells” (SPCs) in bone marrow and identifying, isolating, and characterization of pre-osteoclasts in peripheral blood. By binding to a specific epitope on the cell surface, limbin/EVC-2 detection and separation by conventional cell sorting methodologies are facilitated.
Inventors:
Bowes, Tyrone Villarrard
Glaiser, Udo
Finlay, William James Jonathan
O'Brien, Timothy
Barry, frank
Glaiser, Udo
Finlay, William James Jonathan
O'Brien, Timothy
Barry, frank
Application Number:
JP2009553137A
Publication Date:
June 17, 2010
Filing Date:
March 12, 2008
Export Citation:
Assignee:
National University of Ireland, Galway
International Classes:
C12N15/09; A61K31/7088; A61K35/12; A61K35/14; A61K35/76; A61K38/00; A61K39/395; A61K48/00; A61L15/16; A61L17/00; A61L27/00; A61L31/00; A61P9/00; A61P25/16; A61P25/28; A61P29/00; A61P37/06; A61P43/00; C07K14/47; C07K16/18; C12N1/15; C12N1/19; C12N1/21; C12N5/077; C12N5/10; C12Q1/04
Foreign References:
| WO2002022638A1 | 2002-03-21 |
Other References:
JPN6013001405; Ｈｙｂｒｉｄｏｍａ Ｖｏｌ．２４， Ｎｏ．２, 2005, ｐ．９２-９７
JPN6013001402; Ｃｉｒｃ． Ｊ． Ｖｏｌ．７１， Ｎｏ．Ｓｕｐｐｌｅｍｅｎｔ １, 20070301, ｐ．１４２ ＦＲＳ-０９１
JPN6013001402; Ｃｉｒｃ． Ｊ． Ｖｏｌ．７１， Ｎｏ．Ｓｕｐｐｌｅｍｅｎｔ １, 20070301, ｐ．１４２ ＦＲＳ-０９１
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita