Title:
ガンマ-セクレターゼの活性を阻害するマロンアミド誘導体
Document Type and Number:
Japanese Patent JP4571639
Kind Code:
B2
Abstract:
The invention relates to malonamide derivatives of formula wherein each of the variables are as defined herein and to pharmaceutically acceptable acid addition salts, optically pure enantiomers, racemates and diastereomeric mixtures thereof. These compounds are gamma-secretase inhibitors and may be used for the treatment of Alzheimer's disease.
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Inventors:
Flor, alexander
Flounder, Gweed
Jacop-Rhone, Roland
Kitas, Eric Argylios
Peters, Yens-Uwe
Vostel, Wolfgang
Flounder, Gweed
Jacop-Rhone, Roland
Kitas, Eric Argylios
Peters, Yens-Uwe
Vostel, Wolfgang
Application Number:
JP2006525701A
Publication Date:
October 27, 2010
Filing Date:
August 31, 2004
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
C07D223/16; A61K31/335; A61K31/55; A61K31/5513; A61P25/28; A61P43/00; C07D223/18; C07D223/20; C07D243/14; C07D243/24; C07D273/00; C07D313/14
Domestic Patent References:
| JP2006516556A | ||||
| JP2003534333A | ||||
| JP2004500419A |
Attorney, Agent or Firm:
Hajime Tsukuni
Fusayuki Saito
Yoko Tanaka
Fusayuki Saito
Yoko Tanaka