Title:
Material and a method for determining the susceptibility potential of a compound
Document Type and Number:
Japanese Patent JP6232375
Kind Code:
B2
Abstract:
The invention concerns in vitro proteomic analysis of cells to determine the sensitizing potential (including allergic potential) of compounds on said cells. Several protein markers are provided that allow assays to be performed to determine whether a chemical has a sensitizing potential of contact and/or respiratory sensitizers.
Inventors:
Emma Scofield
Jung, Stephan
Buddha, Petra
Tucht, Hans-Dieter
Zelzer, Stephan
Concare bic, sasa
Kuhn, Karsten
Pike, ian
Jung, Stephan
Buddha, Petra
Tucht, Hans-Dieter
Zelzer, Stephan
Concare bic, sasa
Kuhn, Karsten
Pike, ian
Application Number:
JP2014515293A
Publication Date:
November 15, 2017
Filing Date:
June 18, 2012
Export Citation:
Assignee:
ELECTROPHORETICS LIMITED
International Classes:
G01N33/53; C07K14/47; C07K16/18; C12M1/34; C12N15/09; C12Q1/02; C12Q1/68; G01N33/15; G01N33/50; G01N33/543
Domestic Patent References:
| JP2014522990A | ||||
| JP2010504744A | ||||
| JP2010515020A | ||||
| JP2009508118A |
Foreign References:
| WO2010031799A1 | ||||
| US20090155784 |
Other References:
Ott H et al.,High-resolution transcriptional profiling of chemical-stimulated dendritic cells identifies immunogenic contact allergens, but not prohaptens,Skin pharmacology and physiology,2010年,Vol.23, No.4,Page.213-24
Trompezinski S et al.,Characterization of early events involved in human dendritic cell maturation induced by sensitizers: cross talk between MAPK signalling pathways,Toxicol Appl Pharmacol,2008年,Vol.230, No.3,Page.397-406
Verstraelen S et al.,Gene profiles of a human bronchial epithelial cell line after in vitro exposure to respiratory (non-)sensitizing chemicals: identification of discriminating genetic markers and pathway analysis,Toxicology,2009年,Vol.255, No.3,Page.151-159
Vandebriel Rob J et,Keratinocyte Gene Expression Profiles Discriminate Sensitizing and Irritating Compounds,Toxicol. Sci.,2010年,Vol.117, No.1,Page.81-89
EIAAB,HUMAN PHOSPHOGLUCONATE DEHYDROGENASE, PGD ELISA KIT,[ONLINE],2011年 5月23日,URL,http://www.uscnlife.com.cn/UploadFile/file95902.pdf
PETRA BUDDE,PROTEIN BIOMARKER PROFILES DISCRIMINATE BETWEEN SENSITIZING AND IRRITATING CHEMICALS IN CELL-BASED ASSAYS,[ONLINE],2012年 2月28日,URL,http://www.proteomics.com/docs/20120228_PBudde_SOT12.pdf
KAMIYA BIOMEDICAL COMPANY,HUMAN SUPEROXIDE DISMUTASE 1, SOLUBLE(SOD1) ELISA,[ONLINE],2011年 4月26日,P1-7,URL,http://www.kamiyabiomedical.com/pdf/KT-28990.pdf
VERSTRAELEN SANDRA,GENE PROFILES OF THP-1 MACROPHAGES AFTER IN VITRO EXPOSURE TO RESPIRATORY (NON-) SENSITIZING CHEMICALS: IDENTIFICATION OF DISCRIMINATING GENETIC MARKERS AND PATHWAY ANALYSIS,TOXICOLOGY IN VITRO,英国,ELSEVIER SCIENCE,2009年 9月 1日,V23 N6,P1151-1162
Nathalie Lambrechts,THP-1 monocytes but not macrophages as a potential alternative for CD34+ dendritic cells to identify chemical skin sensitizers,Toxicol Appl Pharmacol,2009年,Vol.236 No.2,Page.221-30
Absolute identification of novel autoimmune biomarkers ProtoArray Human Protein Microarrays,2016年11月 7日,URL,https://www.thermofisher.com/content/dam/LifeTech/migration/en/filelibrary/protein-expression/pdfs.par.16180.file.dat/protoarray%20v5%20irbp-fhr.pdf
Trompezinski S et al.,Characterization of early events involved in human dendritic cell maturation induced by sensitizers: cross talk between MAPK signalling pathways,Toxicol Appl Pharmacol,2008年,Vol.230, No.3,Page.397-406
Verstraelen S et al.,Gene profiles of a human bronchial epithelial cell line after in vitro exposure to respiratory (non-)sensitizing chemicals: identification of discriminating genetic markers and pathway analysis,Toxicology,2009年,Vol.255, No.3,Page.151-159
Vandebriel Rob J et,Keratinocyte Gene Expression Profiles Discriminate Sensitizing and Irritating Compounds,Toxicol. Sci.,2010年,Vol.117, No.1,Page.81-89
EIAAB,HUMAN PHOSPHOGLUCONATE DEHYDROGENASE, PGD ELISA KIT,[ONLINE],2011年 5月23日,URL,http://www.uscnlife.com.cn/UploadFile/file95902.pdf
PETRA BUDDE,PROTEIN BIOMARKER PROFILES DISCRIMINATE BETWEEN SENSITIZING AND IRRITATING CHEMICALS IN CELL-BASED ASSAYS,[ONLINE],2012年 2月28日,URL,http://www.proteomics.com/docs/20120228_PBudde_SOT12.pdf
KAMIYA BIOMEDICAL COMPANY,HUMAN SUPEROXIDE DISMUTASE 1, SOLUBLE(SOD1) ELISA,[ONLINE],2011年 4月26日,P1-7,URL,http://www.kamiyabiomedical.com/pdf/KT-28990.pdf
VERSTRAELEN SANDRA,GENE PROFILES OF THP-1 MACROPHAGES AFTER IN VITRO EXPOSURE TO RESPIRATORY (NON-) SENSITIZING CHEMICALS: IDENTIFICATION OF DISCRIMINATING GENETIC MARKERS AND PATHWAY ANALYSIS,TOXICOLOGY IN VITRO,英国,ELSEVIER SCIENCE,2009年 9月 1日,V23 N6,P1151-1162
Nathalie Lambrechts,THP-1 monocytes but not macrophages as a potential alternative for CD34+ dendritic cells to identify chemical skin sensitizers,Toxicol Appl Pharmacol,2009年,Vol.236 No.2,Page.221-30
Absolute identification of novel autoimmune biomarkers ProtoArray Human Protein Microarrays,2016年11月 7日,URL,https://www.thermofisher.com/content/dam/LifeTech/migration/en/filelibrary/protein-expression/pdfs.par.16180.file.dat/protoarray%20v5%20irbp-fhr.pdf
Attorney, Agent or Firm:
Toru Ishikawa