Title:
眼圧及び頭蓋内圧を調節するための材料及び方法
Document Type and Number:
Japanese Patent JP7430917
Kind Code:
B2
Abstract:
The invention relates to materials and methods for the modulation of intraocular and intracranial pressure, and treatment of associated conditions such as glaucoma and hydrocephalus. More specifically, the invention relates to adenoviral vectors of serotype ShH10, and their therapeutic use in transducing the CRISPR system into ciliary body or choroid plexus to modulate expression of aquaporin or carbonic anhydrase genes.
Inventors:
Chu, Colin Jonathan
Application Number:
JP2020569201A
Publication Date:
February 14, 2024
Filing Date:
June 11, 2019
Export Citation:
Assignee:
The University of Bristol
International Classes:
C12N15/864; A61K35/76; A61K48/00; A61P25/00; A61P27/02; A61P27/06
Domestic Patent References:
| JP2016501531A | ||||
| JP2010540564A |
Foreign References:
| WO2008067382A2 | ||||
| WO2016186772A2 |
Other References:
JAIN, A., et al.,Proceedings of the National Academy of Sciences,2017年,Vol. 114,No. 42,pp. 11199-11204
JIMENEZ, A., et al.,Investigative Ophthalmology & Visual Science,2009年,Vol. 50,p. 4054
JIMENEZ, A., et al.,Investigative Ophthalmology & Visual Science,2009年,Vol. 50,p. 4054
Attorney, Agent or Firm:
Osamu Yamamoto
Toru Miyamae
Junichi Matsuo
Takumi Terachi
Toru Miyamae
Junichi Matsuo
Takumi Terachi