Title:
CD31の発現を阻害する手段
Document Type and Number:
Japanese Patent JP2009535018
Kind Code:
A
Abstract:
The present invention is related to a nucleic acid molecule comprising a double-stranded structure, whereby the double-stranded structure comprises a first strand and a second strand, whereby the first strand comprises a first stretch of contiguous nucleotides and said first stretch is at least partially complementary to a target nucleic acid, and whereby the second strand comprises a second stretch of contiguous nucleotides and said second stretch is at least partially complementary to the first stretch, whereby the first stretch comprises a nucleic acid sequence which is at least complementary to a nucleotide core sequence of the nucleic acid sequence according to SEQ ID NO: 1, whereby the nucleotide core sequence comprises the nucleotide sequence from nucleotide positions 1277 to 1295 of SEQ ID NO: 1; from nucleotide positions 2140 to 2158 of SEQ ID NO:1; from nucleotide positions 2391 to 2409 of SEQ ID NO: 1; and whereby the first stretch is additionally at least partially complementary to a region preceding the 5' end of the nucleotide core sequence and/or to a region following the 3' end of the nucleotide core sequence.
Inventors:
Kaufmann, Jörg
Kyle, Oliver
Zantel, Ansgar
Kyle, Oliver
Zantel, Ansgar
Application Number:
JP2009505788A
Publication Date:
October 01, 2009
Filing Date:
April 20, 2007
Export Citation:
Assignee:
SILENCE THERAPEUTICS AG
International Classes:
C12N15/09; A61K9/127; A61K31/7105; A61K31/713; A61K35/12; A61K35/74; A61K35/76; A61K47/18; A61K47/24; A61K48/00; A61P1/02; A61P1/04; A61P3/04; A61P3/10; A61P7/10; A61P9/00; A61P9/10; A61P9/12; A61P11/00; A61P11/02; A61P11/06; A61P15/00; A61P17/00; A61P17/06; A61P17/12; A61P19/00; A61P19/02; A61P31/04; A61P35/00; A61P37/06; A61P37/08; A61P41/00; C12N5/10; C12N15/113
Foreign References:
| WO2005105152A2 | 2005-11-10 | |||
| WO2006023827A2 | 2006-03-02 |
Other References:
JPN6012019327; ＴＨＥ ＪＯＵＲＮＡＬ ＯＦ ＢＩＯＬＯＧＩＣＡＬ ＣＨＥＭＩＳＴＲＹ ｖｏｌ．２８０ ｎｏ．３３, 2005, ｐｐ．２９６２０-２９６２４
JPN6012019329; Ｊｏｕｒｎａｌ ｏｆ Ｃｅｌｌ Ｓｃｉｅｎｃｅ ｖｏｌ．１１８, 2005, ｐｐ．４１０３-４１１１
JPN6012019332; Ａｎｇｉｏｇｅｎｅｓｉｓ ｖｏｌ．３, 1999, ｐｐ．１８１-１８８
JPN6012019329; Ｊｏｕｒｎａｌ ｏｆ Ｃｅｌｌ Ｓｃｉｅｎｃｅ ｖｏｌ．１１８, 2005, ｐｐ．４１０３-４１１１
JPN6012019332; Ａｎｇｉｏｇｅｎｅｓｉｓ ｖｏｌ．３, 1999, ｐｐ．１８１-１８８
Attorney, Agent or Firm:
Shoichi Okuyama
Arihara Koichi
Matsushima Tetsuo
Hidefumi Kawamura
Naomi Yoshida
Ayako Nakamura
Masayuki Okamoto
Fukagawa Eri
Satoshi Morimoto
Arihara Koichi
Matsushima Tetsuo
Hidefumi Kawamura
Naomi Yoshida
Ayako Nakamura
Masayuki Okamoto
Fukagawa Eri
Satoshi Morimoto