Title:
MEANS FOR MODULATING PROCESS MEDIATED BY RETINOID RECEPTOR AND COMPOUND USEFUL THEREFOR
Document Type and Number:
Japanese Patent JP2007254481
Kind Code:
A
Abstract:
To provide methods for modulating processes mediated by retinoid receptors, by employing high affinity and high specificity ligands for such receptors.
In one aspect, ligands more selective for a retinoid X receptor than retinoic acid (i.e., rexoids) are provided. In another aspect, alternative ligands (other than retinoic acid) inducing retinoic acid receptor-mediated processes have been discovered. In yet another aspect, methods producing such retinoid receptor ligands from readily available compounds have been developed.
COPYRIGHT: (C)2008,JPO&INPIT
Inventors:
EVANS ROLAND M
MANGELSDORF DAVID J
HEYMAN RICHARD A
BOEHM MARCUS F
EICHELE GREGOR
THALLER CHRISTINA
MANGELSDORF DAVID J
HEYMAN RICHARD A
BOEHM MARCUS F
EICHELE GREGOR
THALLER CHRISTINA
Application Number:
JP2007122307A
Publication Date:
October 04, 2007
Filing Date:
May 07, 2007
Export Citation:
Assignee:
SALK INST FOR BIOLOGICAL STUDI
BAYLOR COLLEGE MEDICINE
LIGAND PHARM INC
BAYLOR COLLEGE MEDICINE
LIGAND PHARM INC
International Classes:
A61K31/203; G01N33/566; A61K31/07; A61K31/19; A61K31/20; A61K31/23; A61K31/232; A61K38/52; A61P3/06; A61P17/00; A61P35/00; A61P35/02; A61P43/00; C07C57/26; C07C59/46; C07C59/80; C07C403/00; C07C403/20; C07K14/705; C12P7/04; C12P7/62; C12P7/64; C12P9/00
Attorney, Agent or Firm:
Hideto Asamura
Hajime Asamura
Naganuma Akio
Utamon Shoji
Hajime Asamura
Naganuma Akio
Utamon Shoji
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