PURPOSE: The titled high-safety composition that contains an aminosulfonylhalogenobenzoic acid derivative as an active ingredient, thus being suitably used as a remedy for viral infections such as pneumonia or tracheitis, because of its quick-acting properties.
CONSTITUTION: The objective composition contains an aminosulfonylhalogenobenzoic acid derivative of formulaI(X, Y are H, F, Cl, amino; R1 is H, lower alkyl; R2 is H, amino, lower alkyl; where 3-aminosulfonyl-4-halogenobenzoic acids are excluded) or its salt as a major active ingredient. The compound of formulaIshows a wide range of antiviral activity, for example, against influenza A0 or influenza A1 virus and high safety as well. The compound of formulaIis obtained by heating a halogenobenzoic acid in chlorosulfonic acid and making the resultant chlorosulfonylhalogenobenzoic acid react with an amine of formula II at room temperature in the presence of an acid acceptor such as triethylamine.
| JP2006083133 | MEDICINAL COMPOSITION OF SULFAMIDE DERIVATIVE |
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YAMAGUCHI KAZUO
SUZUKI YASUO
MOCHIDA SUGURU
| JP37015136A |