Medical treatment and a preventing method of secondary hyperparathyroidism - Proventive Therapeutics Limited Liability Company

Title:

Medical treatment and a preventing method of secondary hyperparathyroidism

Document Type and Number:

Japanese Patent JP6023734

Kind Code:

B2

Abstract:

A method of treating elevated blood levels of iPTH by increasing or maintaining blood concentrations of both 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D in a patient by administering, as necessary, both Vitamin D repletion and Vitamin D hormone replacement therapies, is disclosed. The blood concentrations of 25-hydroxyvitamin D are increased to and maintained at or above 30 ng/mL, and blood concentrations of 1,25-dihydroxyvitamin D are increased to or maintained within a patient's normal historical physiological range for 1,25-dihydroxyvitamin D without causing substantially increased risk of hypercalcemia, hyperphosphatemia or over suppression of plasma iPTH in the patient. The blood levels of 25-hydroxyvitamin D are maintained at or above 30 ng/mL between doses of Vitamin D repletion therapies, and the blood levels of 1,25-dihydroxyvitamin D are maintained in the patient's normal historical physiological range between doses of Vitamin D hormone replacement therapies. In one aspect, the disclosure includes methods wherein the blood concentration of 25-hydroxyvitamin D during treatment comprises predominantly 25-hydroxyvitamin D₃, and/or wherein the method includes administering predominantly or solely 25-hydroxyvitamin D₃for 25-hydroxyvitamin D repletion and/or maintenance.

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Inventors:

Bishop Charles W
Crawford Keith H
Messner Eric Jay
Petkovic Martin Pea
Elvig Kristyanev

Application Number:

JP2014031369A

Publication Date:

November 09, 2016

Filing Date:

February 21, 2014

Export Citation:

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Assignee:

Proventive Therapeutics Limited Liability Company
Cytochroma Inc.

International Classes:

A61K31/575; A61K31/592; A61K31/593; A61P3/02; A61P5/20

Domestic Patent References:

JP11158074A
JP55139320A
JP57188520A
JP64031722A

Other References:

Response of chick parathyroid glands to the vitamin D metabolites, 1,25-dihydroxycholecalciferol and 24,25-dihydroxycholecalciferol,Journal of Nutrition,1977年,vol.107,no.10,p.1918-1926

Attorney, Agent or Firm:

Koichi Tsujii
Sadao Kumakura
Atsushi Hakoda
Kenji Asai
Kazuo Yamazaki
Satsuki Ichikawa
Gen Tashiro

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