Title:
Medical treatment of pyrroline 5-carboxylic acid Reductase 1 (PYCR1) associated diseases by prevention of the natural antisense transcript to PYCR1
Document Type and Number:
Japanese Patent JP5976548
Kind Code:
B2
Abstract:
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Pyrroline-5-carboxylate reductase 1 (PYCR1), in particular, by targeting natural antisense polynucleotides of Pyrroline-5-carboxylate reductase 1 (PYCR1). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of PYCR1.
Inventors:
Corrado, Joseph
Corcowa Sherman, Olga
Corcowa Sherman, Olga
Application Number:
JP2012554080A
Publication Date:
August 23, 2016
Filing Date:
February 21, 2011
Export Citation:
Assignee:
Copper RNA, Inc.
International Classes:
C12N15/113; A61K31/7088; A61K31/7115; A61K31/712; A61K31/713; A61K48/00; A61P1/02; A61P1/04; A61P1/16; A61P5/00; A61P9/00; A61P9/10; A61P11/00; A61P13/02; A61P13/08; A61P13/10; A61P13/12; A61P15/00; A61P17/00; A61P17/06; A61P19/00; A61P19/02; A61P19/06; A61P19/10; A61P21/00; A61P25/00; A61P25/04; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P25/24; A61P25/28; A61P27/02; A61P29/00; A61P35/00; A61P35/02; A61P43/00
Domestic Patent References:
| JP2004528045A | ||||
| JP2013516182A | ||||
| JP2013515459A | ||||
| JP2013516191A | ||||
| JP2013516197A | ||||
| JP2013515504A | ||||
| JP2013516175A | ||||
| JP2013515505A | ||||
| JP2013517778A |
Foreign References:
| CN1301851A | ||||
| CN1320635A | ||||
| CN1274728A | ||||
| WO2010014895A1 | ||||
| WO2009099326A1 |
Other References:
J.A. de Ronde et al.,Effect of antsense L-Δ1-pyrroline-5-carboxylate reductase transgenic soybean plants subjected to osmotic and drought stress,Plant Growth Regulation ,1999年11月30日,Vol.32,13-26
Attorney, Agent or Firm:
Ryoichi Takaoka
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