MEDICAL USE OF SELECTIVE ESTROGEN RECEPTOR MODULATOR IN COMBINATION WITH SEX STEROID PRECURSOR

Title:

MEDICAL USE OF SELECTIVE ESTROGEN RECEPTOR MODULATOR IN COMBINATION WITH SEX STEROID PRECURSOR

Document Type and Number:

Japanese Patent JP2013049703

Kind Code:

A

Abstract:

To provide novel methods for the medical treatment and/or inhibition of the development of osteoporosis, breast cancer, hypercholesterolemia, hyperlipidemia or atherosclerosis in susceptible warm-blooded animals including humans.

The methods involve administration of selective estrogen receptor modulator, particularly ones having a structure of general formula (I) and an amount of a sex steroid precursor selected from the group consisting of dehydroepiandrosterone, dehydroepiandrosterone sulfate, androst-5-ene-3β,17β-diol and compounds converted in vivo to one of the foregoing precursor.

Inventors:

LABRIE FERNAND

Application Number:

JP2012248384A

Publication Date:

March 14, 2013

Filing Date:

November 12, 2012

Export Citation:

Click for automatic bibliography generation Help

Assignee:

ENDORECH INC

International Classes:

A61K31/5685; A61K31/133; C07D333/56; A61K31/381; A61K31/40; A61K31/4025; A61K31/403; A61K31/404; A61K31/4436; A61K31/4453; A61K31/453; A61K31/475; A61K31/56; A61K31/565; A61K31/568; A61K31/57; A61K31/66; A61K45/00; A61K45/06; A61P3/06; A61P9/10; A61P15/00; A61P15/02; A61P19/10; A61P21/00; A61P35/00; A61P43/00; C07D209/10; C07D311/60

Domestic Patent References:

JP2007191484A	2007-08-02
JP2002517433A	2002-06-18

Other References:

JPN6010040373; ＥｎｄｏｃｒｉｎｏｌｏｇｙＶｏｌ．１３８, 1997, ｐｐ．４４３５-４４
JPN4006016274; ＡＮＤＲＥ　ＴＲＥＭＢＬＡＹ，　ｅｔ．　ａｌ．: 'ＥＭ-８００，ａ　Ｎｏｖｅｌ　Ａｎｔｉｅｓｔｒｏｇｅｎ，　Ａｃｔｓ　ａｓ　ａ　Ｐｕｒｅ　Ａｎｔａｇｏｎｉｓｔ　ｏｆ　ｔｈｅ　Ｔｒａｎｓｃｒｉｐｔｉｏｎａｌ　Ｆｕｎｃｔｉｏｎｓ　ｏｆ　Ｅｓｔｒｏｇｅｎ' Ｅｎｄｏｃｒｉｎｏｌｏｇｙ１３９（１）, 199801, ｐｐ．１１１-１１８

Attorney, Agent or Firm:

Aoyama Aoi
Takuji Yamada
Michiko Matsutani
Satoshi Hashimoto

Previous Patent: COMPOSITION AND METHOD FOR ENHANCING CONTRAST IN IMAGING

Next Patent: TREATMENT FOR LATENT TUBERCULOSIS