Title:
MEDICINAL COMPOSITION CONTAINING TERFENADINECARBOXYLATE AND NON-STEROIDAL ANTI-INFLAMATORY MEDICINE OR NON- NARCOTIC ANALGESIC MEDICINE
Document Type and Number:
Japanese Patent JP3288661
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To obtain the subject composition capable of avoiding cardiovascular system side effects caused by the administration of terfenadine by adding a terfenadine carboxylate and a non-steroidal anti-inflammatory medicine or non-narcotic analgesic medicine.
SOLUTION: This medicinal composition contains (A) a terfenadine carboxylate {4-[1-hydroxy-4-(4-hydroxydiphenylmethyl-1-piperidinyl)butyl]-α,α- dimethylbenzene acetate, 1[p-(2-hydroxymethylprop-2-yl-phenyl]-4-[4-(α-hydroxy-α- phenylbenzyl)piperidin-1-yl]butanol, etc.}, of the formula (Z is COOH, COOCH3, etc.), which is a metabolic derivative of the terfenadine, and (B) a non-steroidal anti-inflammatory medicine or a non-narcotic analgesic medicine (for example, acetylsalicylate, ibuprofen). The component A and the component B are preferably contained in amounts of 20-200 mg and 25-600 mg, respectively.
Inventors:
Young, James W.
Gray, Nancy M.
Wolseley, Raymond Elle.
Chen, Ewan
Gray, Nancy M.
Wolseley, Raymond Elle.
Chen, Ewan
Application Number:
JP29122399A
Publication Date:
June 04, 2002
Filing Date:
August 03, 1993
Export Citation:
Assignee:
Sepra Core, Incorporated
International Classes:
C07D211/22; A61K9/48; A61K31/137; A61K31/165; A61K31/192; A61K31/445; A61K31/451; A61K31/60; A61K45/00; A61K45/06; A61P17/00; A61P27/16; A61P37/08; A61P43/00; (IPC1-7): A61K31/445; A61K31/165; A61K31/192; A61K31/60; A61P37/08
Attorney, Agent or Firm:
Yusuke Hiraki (2 outside)