Title:
MEDICINAL COMPOSITION FOR INTRAVENOUS ADMINISTRATION OF STAULOSPORIN DERIVATIVE
Document Type and Number:
Japanese Patent JPH08208486
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To obtain the subject composition capable of solubilizing a staurosporine derivative useful as an antiinflammatory agent, etc., in intravenously administrable homogeneity by adding a specific phospholipid, a triglyceride, etc., to the sparingly water-soluble staurosporin derivative. SOLUTION: This composition comprises (A) a sparingly water-soluble staurosporine derivative, (B) a phospholipid of formula I (R1 is a 10-20C acyl; R2 is H, R1 ; R2 is H, 2-trimethylamino-1-ethyl, 2-amino-1-ethyl, a 1-4C alkyl, etc.), or its salt, (C) a triglyceride of formula II (R1 -R3 are each a 8-24C acyl), (D) the partial fatty acid ester of polyoxyethylene-sorbitan, and (E) a liquid carrier water in a purity necessary for intravenous administration.
Inventors:
HANSU GEORUKU UEDAA
UTE IZERU
UTE IZERU
Application Number:
JP28950895A
Publication Date:
August 13, 1996
Filing Date:
November 08, 1995
Export Citation:
Assignee:
CIBA GEIGY AG (CH)
International Classes:
A61K9/107; A61K31/55; A61K31/553; A61K47/14; A61K47/24; A61P9/00; A61P9/10; A61P31/04; A61P35/00; C07D498/22; A61K9/127; (IPC1-7): A61K31/55; A61K31/55; A61K9/107; A61K9/127; A61K47/14; A61K47/24; C07D498/22
Attorney, Agent or Firm:
Takashi Ishida (3 others)