MEDICINAL RESISTANCE OVERCOMING AGENT

Japanese Patent JP3474940

B2

PURPOSE: To obtain a new compound useful as medicinal resistance overcoming agent low in calcium antagonistic activity, provided with the resistance to chemotherapeutic agents, overcoming the medicinal resistance to cancers or pathogenic microbes and improving the therapeutic effect by chemotherapeutic agents.
CONSTITUTION: This compound (a physiologically permissible salt thereof) is expressed by formula I [X and Y are each H or a halogen; (n) is 1-4; R1 is a halogen, 1-4C alkyl, 1-4C alkyloxy, or (nitro-substituted or N-contg.) monocyclic or bicyclic aromatic ring], e.g. 1-(2,2-diphenylethylcarbonyl)-4-[3-(7- chloroquinolin-4-yloxy)-2-hydroxypropyl]piperazine of formula II. The compound of formula I is obtained by the following process: a compound of formula IV is prepared by reaction of a halogen compound of formula III with piperazine; separately, an epoxy compound of formula V is formed by reaction between a compound of formula R1OH and an epihalohydrin in the presence of sodium hydride; and the compound of formula IV and the epoxy compound of formula V are subjected to ring opening condensation reaction.

JP3245642	INDUSTRIAL APPLICABILITY: Substance abuse disorder therapeutic agent
JPH01501310	[Title of the Invention] A prodrug derivative of a carboxylic acid medicine
JPS51125061	A PROCESS FOR 3-ACYLAMINOAZETIDINONE DERIVATIVES

Takao Hattori
Takao Ito
Masahiko Tsuchiya

JP25003494A

December 08, 2003

September 19, 1994

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POLA CHEMICAL INDUSTRIES, INC.

C07D295/18; A61K31/495; A61K31/496; A61K45/00; A61P31/04; A61P33/02; A61P35/00; A61P43/00; C07D215/20; C07D215/22; (IPC1-7): C07D215/20; A61K31/495; A61K31/496; A61P31/04; A61P33/02; A61P35/00; A61P43/00; C07D215/22; C07D295/18

JP6211664A
JP6199669A

Miyuki Ariga (4 outside)

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