PURPOSE: To obtain a compacted oral administration preparation containing a medicinal substance in a high content, easy in tableting, and excellent in disintegrating, eluting and absorbing properties.
CONSTITUTION: 1-80wt.% of a medicinally active ingredient (e.g. thromboxane A2-antagonizing agent) ground into fine particles having particle sizes of ≤30μm by a jet grinding method is mixed with a surfactant (e.g. sodium laurylsulfate) in an amount of 1-2wt.% based on that of the medicinally active ingredient or an organic acid salt (e.g. trisodium citrate) in an amount of 0.5-4wt.% based on the medicinally active ingredient, and subsequently formed into nuclear granules. The granules are mixed with a base agent such as starch partially converted into alpha-starch, and subsequently tableted to obtain the objective medicinal composition. The starch partially converted into the alpha-starch is compounded in an amount of 1-40wt.% based on the medicinally active ingredient. The thromboxane A2-antagonizing agent is e.g. 11-[2-(5,6-dimethyl-1- benzoimidazolyl)ethylidene]-6,1-dihydrodibenzo[b, e]oxepine-2-carboxylic acid or its salt.
SHODA TOMOAKI
SAITOU NAOHIRO
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