To obtain an increase inhibitor for an anti-crystalline lens protein antibody in serum, especially a therapeutic agent, a preventive and a crisis delaying agent for cataract.

This medicine composition comprises a crystalline lens antigen or an antigen developing microorganism as an active ingredient and is especially an increase inhibitor for an anti-crystalline lens protein antibody in serum, specially a therapeutic agent, a preventive and a crisis delaying agent for cataract. The microorgansim is for enteric administration. Since the composition has promising inhbitory actions on increase of anti-crystalline lens protein antibody in serum, it is effectively usable as the therapeutic agent, the preventive and the crisis delaying agent for cataract.